Retrotransposons revisited: the restraint and rehabilitation of parasites.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18854152.
- Also identified by DOI 10.1016/j.cell.2008.09.022.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Retrotransposons, mainly LINEs, SINEs, and endogenous retroviruses, make up roughly 40% of the mammalian genome and have played an important role in genome evolution. Their prevalence in genomes reflects a delicate balance between their further expansion and the restraint imposed by the host. In any human genome only a small number of LINE1s (L1s) are active, moving their own and SINE sequences into new genomic locations and occasionally causing disease. Recent insights and new technologies promise answers to fundamental questions about the biology of transposable elements.
Medical subject headings
- Genome, Human
- Retroelements