Silent synapses and the emergence of a postsynaptic mechanism for LTP.
review · Level V
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- Record sourced from PubMed, PMID 18854855.
- Also identified by DOI 10.1038/nrn2501 and PMC identifier 2819160.
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Abstract
Silent synapses abound in the young brain, representing an early step in the pathway of experience-dependent synaptic development. Discovered amidst the debate over whether long-term potentiation reflects a presynaptic or a postsynaptic modification, silent synapses--which in the hippocampal CA1 subfield are characterized by the presence of NMDA receptors but not AMPA receptors--have stirred some mechanistic controversy of their own. Out of this literature has emerged a model for synapse unsilencing that highlights the central role for postsynaptic AMPA-receptor trafficking in the expression of excitatory synaptic plasticity.
Medical subject headings
- Excitatory Postsynaptic Potentials
- Long-Term Potentiation
- Synapses