Decreased expression of class II major histocompatibility complex (MHC) molecules on monocytes is found in open-heart surgery related immunosuppression.
case_series · Level IV
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Abstract
The expression of class II major histocompatibility complex (MHC) molecules on monocytes and the relative proportion of immunoregulatory lymphocyte subpopulations were studied from the blood of eight patients undergoing a cardiac operation. The aim of the study was to reveal mechanisms responsible for depression of cellular immunity and B-lymphocyte activation associated with open-heart surgery. A decreased staining of HLA-DR and even more of HLA-DQ class II MHC molecules was found on the monocyte surface in samples taken 2 and 7 days after operation when compared to preoperative values. The relative proportion of monocytes in mononuclear cells increased after surgery, but within lymphocyte subpopulations only a decrease in total T cells and an increased number of activated (HLA-DR positive) T cells were found, whereas the rations between various T cells subsets remained relatively stable.
Medical subject headings
- Cardiac Surgical Procedures
- Gene Expression
- Genes, MHC Class I
- Immune Tolerance
- Monocytes