Globoid cell leukodystrophy: a family with both late-infantile and adult type.

Verdru, P; Lammens, M; Dom, R; Van Elsen, A; Carton, H · Neurology · 1991

case_report · Level V

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Abstract

We present a patient with adult-onset globoid cell leukodystrophy (GBL) who had almost complete deficiency of galactosylceramide beta-galactosidase. A brother of the index patient deteriorated neurologically and died at the age of 4, probably from the late-infantile form of the disease. In this family, two clinical types of GBL are probably different expressions of an identical genotype.

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