Alphav integrins lead the way for colorectal metastases.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18927272.
- Also identified by DOI 10.1158/1078-0432.CCR-08-1847 and PMC identifier 2688736.
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Abstract
In this issue of Clinical Cancer Research, Conti et al. identify a crucial cell adhesion and signaling axis that promotes the proliferation, survival, and drug-resistant properties of metastatic colorectal cancer cells in the liver. The components of this pathway may be effective targets for therapeutically treating established metastatic tumors in patients with colorectal adenocarcinomas.
Medical subject headings
- Adenocarcinoma
- Colorectal Neoplasms
- Integrin alphaV
- Liver Neoplasms