Feedback loops shape cellular signals in space and time.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18927383.
- Also identified by DOI 10.1126/science.1160617 and PMC identifier 2680159.
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Abstract
Positive and negative feedback loops are common regulatory elements in biological signaling systems. We discuss core feedback motifs that have distinct roles in shaping signaling responses in space and time. We also discuss approaches to experimentally investigate feedback loops in signaling systems.
Medical subject headings
- Calcium Signaling
- Feedback, Physiological
- Neutrophils
- Phosphatidylinositol 3-Kinases
- Signal Transduction