WAVECLOCK: wavelet analysis of circadian oscillation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18931366.
- Also identified by DOI 10.1093/bioinformatics/btn521 and PMC identifier 2639275.
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Abstract
Oscillations in mRNA and protein of circadian clock components can be continuously monitored in vitro using synchronized cell lines. These rhythms can be highly variable due to culture conditions and are non-stationary due to baseline trends, damping and drift in period length. We present a technique for characterizing the modal frequencies of oscillation using continuous wavelet decomposition to non-parametrically model changes in amplitude and period while removing baseline effects and noise. The method has been implemented as the package waveclock for the free statistical software program R and is available for download from http://cran.r-project.org/
Medical subject headings
- Circadian Rhythm
- Computational Biology