Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18939808.
- Also identified by DOI 10.1021/nl801958b and PMC identifier 2629801.
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Abstract
High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by incorporation of gold, iron oxide, or quantum dot nanocrystals for computed tomography, magnetic resonance, and fluorescence imaging, respectively. By including additional labels in the corona of the particles, they were made multifunctional. The characteristics of these nanoparticles, as well as their in vitro and in vivo behavior, revealed that they closely mimic native HDL.
Medical subject headings
- Contrast Media
- Lipoproteins, HDL
- Metal Nanoparticles