Massively parallel production of lipid microstructures.

West, Jonathan; Manz, Andreas; Dittrich, Petra S · Lab Chip · 2008

basic_science · Level V

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Abstract

In this paper we describe a simple and inexpensive microfluidic system for the production of lipid tubules and vesicles. The system incorporates a central microporous membrane for interfacing lipid films with aqueous flows. Hydrodynamic drag was used for the parallel elongation of high axial ratio lipid tubules with uniform 1.5 +/- 0.5 microm diameters. Alternatively, electrokinetic operation was used for the rapid and continuous production of vast numbers of lipid vesicles with diameters ranging from 1 to 3 microm.

Medical subject headings