SPOCTOPUS: a combined predictor of signal peptides and membrane protein topology.
other · Level V
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- Record sourced from PubMed, PMID 18945683.
- Also identified by DOI 10.1093/bioinformatics/btn550.
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Abstract
SPOCTOPUS is a method for combined prediction of signal peptides and membrane protein topology, suitable for genome-scale studies. Its objective is to minimize false predictions of transmembrane regions as signal peptides and vice versa. We provide a description of the SPOCTOPUS algorithm together with a performance evaluation where SPOCTOPUS compares favorably with state-of-the-art methods for signal peptide and topology predictions. SPOCTOPUS is available as a web server and both the source code and benchmark data are available for download at http://octopus.cbr.su.se/
Medical subject headings
- Algorithms
- Membrane Proteins
- Protein Sorting Signals