De novo formation of a subnuclear body.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18948503.
- Also identified by DOI 10.1126/science.1165216.
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Abstract
The mammalian cell nucleus contains structurally stable functional compartments. We show here that one of them, the Cajal body (CB), can be formed de novo. Immobilization on chromatin of both CB structural components, such as coilin, and functional components of the CB, such as the SMN complex, spliceosomal small nuclear ribonucleoproteins (RNPs), small nucleolar RNPs, and small Cajal body-specific RNPs, is sufficient for the formation of a morphologically normal and apparently functional CB. Biogenesis of the CB does not follow a hierarchical assembly pathway and exhibits hallmarks of a self-organizing structure.
Medical subject headings
- Coiled Bodies
- Nuclear Proteins
- Ribonucleoproteins, Small Nuclear
- SMN Complex Proteins