Ageing, oxidative stress and cancer: paradigms in parallax.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18948997.
- Also identified by DOI 10.1038/nrc2522 and PMC identifier 2603471.
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Abstract
Two paradigms central to geroscience research are that aging is associated with increased oxidative stress and increased cancer risk. Therefore, it could be deduced that cancers arising with ageing will show evidence of increased oxidative stress. Recent studies of gene expression in age-controlled breast cancer cases indicate that this deduction is false, posing parallax views of these two paradigms, and highlighting the unanswered question: does ageing cause or simply permit cancer development?
Medical subject headings
- Aging
- Neoplasms
- Oxidative Stress