BASH: a tool for managing BeadArray spatial artefacts.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18953044.
- Also identified by DOI 10.1093/bioinformatics/btn557 and PMC identifier 2639304.
- Licence recorded as CC BY-NC.
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Abstract
With their many replicates and their random layouts, Illumina BeadArrays provide greater scope fordetecting spatial artefacts than do other microarray technologies. They are also robust to artefact exclusion, yet there is a lack of tools that can perform these tasks for Illumina. We present BASH, a tool for this purpose. BASH adopts the concepts of Harshlight, but implements them in a manner that utilizes the unique characteristics of the Illumina technology. Using bead-level data, spatial artefacts of various kinds can thus be identified and excluded from further analyses. The beadarray Bioconductor package (version 1.10 onwards), www.bioconductor.org
Medical subject headings
- Artifacts
- Oligonucleotide Array Sequence Analysis
- Software