SH3BP2 is a critical regulator of macrophage and osteoclast response to M-CSF and RANKL stimulation.
basic_science · Level V
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- Record sourced from PubMed, PMID 18953613.
- Also identified by DOI 10.1007/s11420-008-9091-6 and PMC identifier 2642551.
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Abstract
The protein Src homology 3 domain-binding protein 2 (SH3BP2) is a regulator of tumor necrosis factor (TNF)-alpha generation in macrophages and of osteoclast differentiation. SH3BP2 regulates bone marrow monocyte responses to macrophage and osteoclast differentiation signals downstream of the receptors for macrophage colony-stimulating factor and receptor activator of nuclear factor kappaB ligand. SH3BP2 is a potential target for the development of novel anti-TNF-alpha therapeutic interventions as well as a target for suppression of osteoclastogenesis.