Tie me up, tie me down: inhibiting RNA polymerase.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18957193.
- Also identified by DOI 10.1016/j.cell.2008.09.052 and PMC identifier 4443808.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Mechanistic understanding of antibiotic action can yield crucial insights that aid in the design of new antibiotics. In this issue, Mukhopadhyay et al. (2008) uncover the mechanism by which the antibiotic myxopyronin inhibits bacterial RNA polymerase, suggesting a new target region in RNA polymerase for inhibitor design.
Medical subject headings
- Anti-Bacterial Agents
- Bacterial Proteins
- DNA-Directed RNA Polymerases