A ubiquitin-like protein unleashes ubiquitin ligases.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18957195.
- Also identified by DOI 10.1016/j.cell.2008.09.049.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Modification of cullin-RING ubiquitin ligases by the ubiquitin-like molecule Nedd8 promotes substrate ubiquitination. A crystal structure of a cullin modified by Nedd8 recently reported in Cell (Duda et al., 2008) and a biochemical study in Molecular Cell (Saha and Deshaies, 2008) reveal the dramatic impact on the ligase machinery by conjugation of ubiquitin or ubiquitin-like proteins.
Medical subject headings
- Ubiquitin-Protein Ligase Complexes
- Ubiquitins