Kinetochores and microtubules wed without a ring.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18957196.
- Also identified by DOI 10.1016/j.cell.2008.10.001 and PMC identifier 2867616.
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Abstract
Proper chromosome segregation in mitosis requires tethering of spindle microtubules to the kinetochore. Using electron tomography of mammalian cells, McIntosh et al. (2008) now report the presence of fibrils that connect the inner kinetochore to the curved protofilaments at microtubule ends, suggesting a new model for force generation in chromosome movement.
Medical subject headings
- Kinetochores
- Microtubules