Ensuring an exit strategy: RTEL1 restricts rogue recombination.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18957197.
- Also identified by DOI 10.1016/j.cell.2008.10.003.
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Abstract
Success of homologous recombination-based DNA repair depends not only on recombinases, which promote invasion of the homologous DNA duplex that serves as a template for repair, but also on antirecombinases, which dismantle recombination intermediates to allow completion of repair. In this issue, Barber et al. (2008) identify a previously elusive antirecombinase activity important for maintaining genome stability in animals.
Medical subject headings
- DNA Helicases
- DNA Repair
- Recombination, Genetic