Stress analgesia: the opioid analgesia of long swims suppresses the non-opioid analgesia induced by short swims in mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 1896213.
- Also identified by DOI 10.1016/0304-3959(91)90038-Y.
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Abstract
In mice, room temperature swimming for as short a period as 15 sec has been found to induce a non-opioid analgesia with a time course of 10-12 min. As the duration of the swim is increased, an opioid analgesia develops with a longer persistence (25-30 min); the development of the opioid analgesia appears to suppress the expression of the non-opioid analgesia so that none of the latter is evident after 3 min swims. The characteristics of the tail-flick nociceptive test are also described.
Medical subject headings
- Analgesia
- Endorphins
- Stress, Physiological