Just say no to ATOH: how HIC1 methylation might predispose medulloblastoma to lineage addiction.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18974104.
- Also identified by DOI 10.1158/0008-5472.CAN-08-1904 and PMC identifier 2702666.
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Abstract
Hypermethylated in cancer-1 (HIC1) is a tumor suppressor frequently targeted for promoter hypermethylation in medulloblastoma, an embryonal tumor of the cerebellum. Recently, we showed that HIC1 is a direct transcriptional repressor of ATOH1, a proneural transcription factor required for normal cerebellar development, as well as for medulloblastoma cell viability. Because demethylating agents can induce reexpression of silenced tumor suppressors, restoring HIC1 function may present an attractive therapeutic avenue in medulloblastoma by exploiting an apparent addiction to ATOH1.
Medical subject headings
- Basic Helix-Loop-Helix Proteins
- DNA Methylation
- Kruppel-Like Transcription Factors
- Medulloblastoma