Comment on "Differential rescue of light- and food-entrainable circadian rhythms".
Level V
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- Record sourced from PubMed, PMID 18974333.
- Also identified by PMC identifier 2583785.
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Abstract
Fuller et al. (Reports, 23 May 2008, p. 1074) reported that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food-entrained circadian rhythms. We report that mice bearing a null mutation of Bmal1 exhibit normal food-anticipatory circadian rhythms. Lack of food anticipation in Bmal1-/- mice reported by Fuller et al. may reflect morbidity due to weight loss, thus raising questions about their conclusions.
Medical subject headings
- Basic Helix-Loop-Helix Proteins
- Biological Clocks
- Circadian Rhythm
- Dorsomedial Hypothalamic Nucleus
- Food
- Light