Calcimimetics, parathyroid hormone, and vascular calcification in chronic kidney disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18974757.
- Also identified by DOI 10.1038/ki.2008.417.
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Abstract
Vascular calcification (VC) occurs frequently in chronic kidney disease, contributing to cardiovascular mortality. Numerous risk factors have been identified, including renal osteodystrophy and bone turnover, with low turnover as a main determinant. Other reports support high turnover as a factor in VC. Calcimimetics, which lower serum parathyroid hormone, and parathyroidectomy each prevented VC induced by five-sixths nephrectomy in rats. These results favor increased bone turnover due to hyperparathyroidism, instead of low turnover, as a factor in VC in uremia.
Medical subject headings
- Calcinosis
- Parathyroid Hormone
- Renal Insufficiency, Chronic