Longitudinal MRI study in schizophrenia patients and their healthy siblings.
Level III
Where this comes from
- Record sourced from PubMed, PMID 18978326.
- Also identified by DOI 10.1192/bjp.bp.107.041467.
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Abstract
To investigate whether genetic and/or disease-related factors are involved in progressive structural brain changes in schizophrenia, magnetic resonance imaging scans with a 5-year scan interval were acquired in patients, their same-gender siblings and matched healthy controls. Structural equation modelling was applied to assess disease and familial effects. Whole brain and cerebral grey matter volumes decreased excessively in patients compared with their siblings and the controls, suggesting that the progressive brain loss in schizophrenia may be related to the disease process.
Medical subject headings
- Cerebral Cortex
- Magnetic Resonance Imaging
- Schizophrenia
- Siblings