Complement activation during bypass in acquired C1 esterase inhibitor deficiency.
case_report · Level V
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- Record sourced from PubMed, PMID 1898144.
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Abstract
Serial complement estimations during cardiopulmonary bypass are reported in a patient with acquired C1 esterase inhibitor deficiency. Although the extent of classic and alternative pathway activation appeared appropriate, exaggerated common pathway activation with massive increase in the C3d:C3 ratio occurred. A fatal hemostatic disorder, pulmonary edema, and circulatory collapse ensued despite prophylaxis and therapy.
Medical subject headings
- Cardiopulmonary Bypass
- Complement Activation
- Complement C1 Inactivator Proteins