Ink4a/Arf regulation by let-7b and Hmga2: a genetic pathway governing stem cell aging.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18983959.
- Also identified by DOI 10.1016/j.stem.2008.10.008.
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Abstract
Stem cell self-renewal capacity declines with age. In a recent issue of Cell, Nishino and colleagues (2008) show that Hmga2 maintains neural stem cell (NSC) function in young mice through repression of the Ink4a/Arf locus; in contrast, during aging, elevated let-7b blocks Hmga2 and contributes to declining NSC function.
Medical subject headings
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p16
- HMGA2 Protein
- MicroRNAs
- Neurons
- Stem Cells
- Tumor Suppressor Protein p14ARF