The autistic neuron: troubled translation?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18984149.
- Also identified by DOI 10.1016/j.cell.2008.10.017.
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Abstract
Autism is a complex genetic disorder, but single-gene disorders with a high prevalence of autism offer insight into its pathogenesis. Recent evidence suggests that some molecular defects in autism may interfere with the mechanisms of synaptic protein synthesis. We propose that aberrant synaptic protein synthesis may represent one possible pathway leading to autistic phenotypes, including cognitive impairment and savant abilities.
Medical subject headings
- Autistic Disorder
- Nerve Tissue Proteins
- Neurons
- Protein Biosynthesis