It takes a (dysfunctional) village to raise a tumor.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18984150.
- Also identified by DOI 10.1016/j.cell.2008.10.009 and PMC identifier 2693258.
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Abstract
The tumor microenvironment is known to play an important role in tumorigenesis. In this issue, Yang et al. (2008) demonstrate that mast cells heterozygous for the Nf1 gene promote the growth of neurofibromas in a mouse model of neurofibromatosis and that genetic and pharmacological inhibition of these cells is sufficient to block tumor growth.
Medical subject headings
- Mast Cells
- Neurofibroma