Genetic mapping in human disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18988837.
- Also identified by DOI 10.1126/science.1156409 and PMC identifier 2694957.
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Abstract
Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.
Medical subject headings
- Chromosome Mapping
- Disease
- Genome, Human
- Genome-Wide Association Study