Intravital imaging of metastatic behavior through a mammary imaging window.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18997781.
- Also identified by DOI 10.1038/nmeth.1269 and PMC identifier 2820719.
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Abstract
We report a technique to evaluate the same tumor microenvironment over multiple intravital imaging sessions in living mice. We optically marked individual tumor cells expressing photoswitchable proteins in an orthotopic mammary carcinoma and followed them for extended periods through a mammary imaging window. We found that two distinct microenvironments in the same orthotopic mammary tumor affected differently the invasion and intravasation of tumor cells.
Medical subject headings
- Image Enhancement
- Mammary Neoplasms, Experimental
- Microscopy