Effect of arterial carbon dioxide tension on the duration of action of atracurium.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 1900014.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The duration of action of atracurium was studied in two groups of patients. In group I (n = 15), patients' lungs were hyperventilated to a mean PaCO2 of 3.3 kPa and in group II (n = 15) lungs were ventilated to maintain a mean PaCO2 of 5.3 kPa. Anaesthesia was maintained using an infusion of propofol. The time taken to return to a T1 twitch height of 10% of control was measured following each incremental dose of atracurium 0.15 mg kg-1. It was found that the duration of action of atracurium was significantly (P less than 0.0005) shorter in the hypocapnic group.
Medical subject headings
- Atracurium
- Carbon Dioxide