Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides.
basic_science · Level V
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- Record sourced from PubMed, PMID 1900456.
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Abstract
We describe functional simplified T cell and Fc receptor chimeras that are capable of directing CD8+ cytotoxic T lymphocytes (CTLs) to specifically recognize and lyse cells expressing HIV envelope proteins. Target cells bearing HLA-DR molecules are not recognized by CTL armed with the chimeras. The variety of cell types in which the native receptors are active suggests multiple possibilities for antiviral intervention through genetic means.
Medical subject headings
- CD4 Antigens
- HIV
- Receptors, Antigen, T-Cell
- Receptors, Fc
- Viral Envelope Proteins