GammaH2AX and cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19005492.
- Also identified by DOI 10.1038/nrc2523 and PMC identifier 3094856.
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Abstract
Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing gammaH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to cancer but, paradoxically, are also used to kill cancer cells. Using gammaH2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs.
Medical subject headings
- DNA Breaks, Double-Stranded
- DNA Damage
- Histones
- Neoplasms