Expanding targets of vitamin D receptor activation: downregulation of several RAS components in the kidney.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19008907.
- Also identified by DOI 10.1038/ki.2008.424.
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Abstract
Vitamin D receptor (VDR) activation has a beneficial influence on the progression of experimental renal insufficiency, and reduced renal tissue renin expression may play a role in this process. Freundlich and co-workers now report that VDR activation also suppresses the expression of angiotensinogen, angiotensin II type 1 receptor, and renin receptor in the kidneys of 5/6 nephrectomized rats, effects associated with reduced blood pressure and urinary protein excretion and with alleviated renal tissue damage.
Medical subject headings
- Gene Expression Regulation
- Kidney
- Receptors, Calcitriol
- ras Proteins