Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone.
editorial · Level V
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- Record sourced from PubMed, PMID 19008908.
- Also identified by DOI 10.1038/ki.2008.477 and PMC identifier 2944250.
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Abstract
This Commentary aims to integrate or interrelate the available data with the current study by Chiga and co-workers, which defines an important influence of aldosterone in the phosphorylation and thus activation of the Na(+)-Cl(-) cotransporter (NCC) in response to changes in NaCl intake and implicates the involvement of SPAK/OSR1 kinases and WNKs.
Medical subject headings
- Aldosterone
- Protein Serine-Threonine Kinases
- Sodium Chloride
- Sodium Chloride Symporters