Limited utility of rapamycin in severe, refractory Wegener's granulomatosis.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 19012360.
- Also identified by DOI 10.3899/jrheum.080664.
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Abstract
We report our experience using rapamycin in patients with Wegener's granulomatosis (WG) who failed to achieve remission with conventional treatment. Eight patients received rapamycin for severe, refractory WG. Clinical outcomes were reviewed retrospectively. Four patients treated with rapamycin sustained remissions of at least 6 months' duration while receiving prednisone<or=10 mg/day; 2 relapsed during followup. Five patients discontinued rapamycin due to continued disease activity, cancer, or adverse events. Toxicities due to rapamycin were numerous; consistent proof of efficacy in this pilot experience with WG was not seen.
Medical subject headings
- Granulomatosis with Polyangiitis
- Immunosuppressive Agents
- Sirolimus