Ovarian ageing, follicle depletion, and cancer: a hypothesis for the aetiology of epithelial ovarian cancer involving follicle depletion.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19012860.
- Also identified by DOI 10.1016/S1470-2045(08)70281-X and PMC identifier 2713057.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The association between ovarian cancer risk and reproductive factors has been well established, and two main theories, incessant ovulation and gonadotropin stimulation, have been proposed to explain the mechanism. Recent studies using animal models of ovarian tumorigenesis, and analysis of ovarian tissues from prophylactic oophorectomies, suggest that depletion of ovarian follicles might underlie the epidemiological findings linking reproductive history and ovarian cancer risk.
Medical subject headings
- Neoplasms, Glandular and Epithelial
- Ovarian Follicle
- Ovarian Neoplasms
- Postmenopause