Finding the right partner: science or ART?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19013267.
- Also identified by DOI 10.1016/j.cell.2008.10.032.
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Abstract
In response to environmental cues, certain plasma membrane proteins are ubiquitinated, signaling their endocytosis and degradation. In the budding yeast, a single enzyme, Rsp5, is charged with this task. Lin et al. (2008) now identify an arrestin-related family of Rsp5 adaptor proteins called ARTs that confer specificity on the ubiquitination of plasma membrane proteins and contribute to the maintenance of the correct cell surface protein repertoire.
Medical subject headings
- Fungal Proteins
- Saccharomyces cerevisiae Proteins