The safety on the TCR trigger.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19013269.
- Also identified by DOI 10.1016/j.cell.2008.10.033 and PMC identifier 2905657.
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Abstract
In this issue, Xu et al. (2008) provide evidence for a new mechanism of T cell receptor regulation. Prior to activation, basic residues in the cytoplasmic domain of the signaling subunits of the T cell receptor associate with the plasma membrane such that the key signaling tyrosines are sequestered in the bilayer.
Medical subject headings
- Gene Expression Regulation
- Receptors, Antigen, T-Cell