Hypothyroidism and dyshormonogenesis induced by D-penicillamine in children with Wilson's disease and healthy infants born to a mother with Wilson's disease.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 19014823.
- Also identified by DOI 10.1016/j.jpeds.2008.06.015.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Two siblings born to a mother with Wilson's disease, who was taking D-penicillamine, developed transient goitrous hypothyroidism. A prospective evaluation of 5 patients with Wilson's disease taking and not taking D-penicillamine for as long as 9.5 years showed subclinical hypothyroidism. D-penicillamine probably inhibited thyroperoxidase activity in utero in healthy infants and during childhood in patients with Wilson's disease.
Medical subject headings
- Chelating Agents
- Goiter
- Hepatolenticular Degeneration
- Hypothyroidism
- Penicillamine