Evaluation of mifepristone as a once a month contraceptive pill.

Agarwal, Mukta; Das, Vinita; Agarwal, Anjoo; Pandey, Amita; Srivastava, Deepali · Am J Obstet Gynecol · 2009

case_control · Level III

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Abstract

The purpose of this study was to assess the efficacy and safety of mifepristone as a contraceptive pill. A prospective case-control study was conducted in a tertiary care center of North India. The study group (n = 86) was given 200-mg mifepristone tablets on the 16th day of the menstrual cycle. The control group (n = 92) received combined oral contraceptive (COC) as per protocol. Subjects were followed for drug compliance, satisfaction, side effects, and failure. Acceptability of mifepristone was significantly higher in educated population (P < .001), with fewer side effects (P = .001), good satisfaction (P < .001), and higher compliance rate (P = .05). The oral contraceptive pill group had higher adverse biochemical parameters. Mifepristone can be used as a monthly contraceptive pill effectively.

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