Recurrent chromosomal abnormalities in human embryonic stem cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 19029912.
- Also identified by DOI 10.1038/nbt.1510.
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Abstract
Cultured human embryonic stem (hES) cells have a known predisposition to aneuploidy of chromosomes 12, 17 and X. We studied 17 hES cell lines by array-based comparative genomic hybridization (aCGH) and found that the cells accumulate other recurrent chromosomal abnormalities, including amplification at 20q11.21 and a derivative chromosome 18. These genomic changes have a variable impact at the transcriptional level.
Medical subject headings
- Chromosome Aberrations
- Chromosomes, Human, Pair 18
- Chromosomes, Human, Pair 20
- Embryonic Stem Cells