Human embryonic stem cells reveal recurrent genomic instability at 20q11.21.
basic_science · Level V
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- Record sourced from PubMed, PMID 19029913.
- Also identified by DOI 10.1038/nbt.1509.
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Abstract
By analyzing five human embryonic stem (hES) cell lines over long-term culture, we identified a recurrent genomic instability in the human genome. An amplification of 2.5-4.6 Mb at 20q11.21, encompassing approximately 23 genes in common, was detected in four cell lines of different origins. This amplification, which has been associated with oncogenic transformation, may provide a selective advantage to hES cells in culture.
Medical subject headings
- Chromosomes, Human, Pair 20
- Embryonic Stem Cells
- Genomic Instability