Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain.
basic_science · Level V
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Abstract
Ha-Ras augments c-Jun-mediated transactivation by potentiating the activity of the c-Jun activation domain. Ha-Ras also causes a corresponding increase in phosphorylation of specific sites in that part of the c-Jun protein. A Ha-Ras-induced protein kinase cascade resulting in hyperphosphorylation of the c-Jun activation domain could explain how these oncoproteins cooperate to transform rat embryo fibroblasts.
Medical subject headings
- DNA-Binding Proteins
- Gene Expression Regulation
- Proto-Oncogene Proteins p21(ras)
- Proto-Oncogenes
- Transcription Factors