When the gut talks to bone.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19041744.
- Also identified by DOI 10.1016/j.cell.2008.11.007.
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Abstract
Mutations in LRP5, a coreceptor for Wnt proteins, cause the disease osteoporosis pseudoglioma. A new study by Yadav et al. (2008) now challenges the view that LRP5 controls bone mass through Wnt signaling in bone and argues instead that LRP5 regulates bone mass indirectly through its effects on serotonin synthesis in the gut.
Medical subject headings
- Bone and Bones
- Gastrointestinal Tract
- LDL-Receptor Related Proteins