Aging: a sirtuin shake-up?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19041745.
- Also identified by DOI 10.1016/j.cell.2008.11.008.
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Abstract
The yeast sirtuin (Sir2) is a histone deacetylase that modulates yeast replicative life span by suppressing genome instability through chromatin modification. In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells.
Medical subject headings
- Aging
- Sirtuins