A two-step pathway to resist fasting.
Where this comes from
- Record sourced from PubMed, PMID 19041759.
- Also identified by DOI 10.1016/j.cmet.2008.11.003.
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Abstract
All vertebrate animals have developed a sophisticated regulatory system to cope with frequent and unpredictable episodes of fasting. A recent letter to Nature suggests that a switch from early gluconeogenic gene activation via CRTC2 (also known as TORC2) to late action of FOXO1 is critical to this process.
Medical subject headings
- Fasting
- Gluconeogenesis