A cholesterol toggle switch.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19041760.
- Also identified by DOI 10.1016/j.cmet.2008.11.006.
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Abstract
Cholesterol levels in mammalian cells are controlled by an intricate mechanism in which the transcription factor SREBP plays a key role. Work in this issue (Radhakrishnan et al., 2008) employing direct measurement of endoplasmic reticulum cholesterol levels offers insights into the "switch" that controls this system with surprising precision.
Medical subject headings
- Cholesterol
- Sterol Regulatory Element Binding Proteins