ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19041769.
- Also identified by DOI 10.1016/j.stem.2008.11.004.
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Abstract
In this issue of Cell Stem Cell, Di Giorgio et al. (2008) and Marchetto et al. (2008) culture motor neurons derived from human embryonic stem cells with astrocytes expressing mutant SOD1. In these human ALS models, motor neurons are selectively destroyed by mutant astrocyte-secreted factors, and potential neuroprotective pathways are revealed.
Medical subject headings
- Amyotrophic Lateral Sclerosis
- Astrocytes
- Embryonic Stem Cells
- Motor Neurons
- Nerve Degeneration