An EZ mark to miss.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19041770.
- Also identified by DOI 10.1016/j.stem.2008.11.007 and PMC identifier 2704610.
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Abstract
Ezh2, the methyltransferase within Polycomb Repressive II Complexes, was thought to be essential for all H3K27me3 marks in embryonic stem cells (ESCs). Recently in Molecular Cell, Shen and colleagues (2008) revealed that EZH2 is dispensable for ESC derivation and self-renewal, and that EZH1 may unexpectedly compensate for its loss.
Medical subject headings
- Drosophila Proteins
- Embryonic Development
- Epigenesis, Genetic
- Gene Expression Regulation, Developmental
- Histone-Lysine N-Methyltransferase
- Repressor Proteins