Overcoming obstacles in the search for the site of hematopoietic stem cell emergence.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19041773.
- Also identified by DOI 10.1016/j.stem.2008.11.002 and PMC identifier 2756073.
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Abstract
The murine embryo has become a valuable tool to examine the ontogeny of hematopoiesis. However, the onset of the systemic circulation has long been a confounding developmental variable that may mask the site of blood cell emergence. This Minireview examines some approaches that have been applied to overcome this obstacle.
Medical subject headings
- Cell Lineage
- Hematopoiesis
- Hematopoietic Stem Cells
- Neovascularization, Physiologic